Drug Information

Drug General Information
Drug ID
D04KQT
Former ID
DIB019773
Drug Name
dodecyl-thiophosphate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542019]
Formula
C12H27O3PS
InChI
InChI=1S/C12H27O3PS/c1-2-3-4-5-6-7-8-9-10-11-12-15-16(13,14)17/h2-12H2,1H3,(H2,13,14,17)
InChIKey
ISWBBUXCFWZBKC-UHFFFAOYSA-N
PubChem Compound ID
10468943
PubChem Substance ID
16498760, 22799627, 40596548, 80905246, 103457672, 104057240, 128215567, 134342529, 137136246, 139637353, 178103569, 226425365
Target and Pathway
Target(s) LPA2 receptor Target Info Agonist [527648]
Lysophosphatidate-3 receptor Target Info Antagonist [527648]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Pathways in cancer
Pathway Interaction Database LPA receptor mediated events
Reactome G alpha (q) signalling events
G alpha (i) signalling events
Lysosphingolipid and LPA receptors
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 542019(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6990).
Ref 527648J Med Chem. 2005 Jul 28;48(15):4919-30.Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin.

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