Drug Information

Drug General Information
Drug ID
D09MLQ
Former ID
DIB019336
Drug Name
compound 20
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531734], [541692]
Formula
C22H21NO6S
InChI
InChI=1S/C22H21NO6S/c1-12(2)21(22(24)25)23-30(26,27)15-6-7-16-17-10-14(18-8-4-13(3)28-18)5-9-19(17)29-20(16)11-15/h4-12,21,23H,1-3H3,(H,24,25)/t21-/m0/s1
InChIKey
LLJREHOWNIBILL-NRFANRHFSA-N
PubChem Compound ID
25122902
PubChem Substance ID
56447087, 81008407, 136924606, 136965026, 178103182, 229122071, 246790461
Target and Pathway
Target(s) MMP-12 Target Info Inhibitor [531734]
NetPath Pathway IL1 Signaling Pathway
IL5 Signaling Pathway
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
WikiPathways TGF beta Signaling Pathway
Degradation of collagen
Matrix Metalloproteinases
References
Ref 531734Discovery of potent and selective matrix metalloprotease 12 inhibitors for the potential treatment of chronic obstructive pulmonary disease (COPD). Bioorg Med Chem Lett. 2012 Jan 1;22(1):138-43.
Ref 541692(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6568).
Ref 531734Discovery of potent and selective matrix metalloprotease 12 inhibitors for the potential treatment of chronic obstructive pulmonary disease (COPD). Bioorg Med Chem Lett. 2012 Jan 1;22(1):138-43.

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