Drug Information

Drug General Information
Drug ID
D0W2FU
Former ID
DIB020370
Drug Name
ML277
Synonyms
ML-277; ML 277
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542644]
Formula
C23H25N3O4S2
InChI
InChI=1S/C23H25N3O4S2/c1-16-6-12-19(13-7-16)32(28,29)26-14-4-3-5-21(26)22(27)25-23-24-20(15-31-23)17-8-10-18(30-2)11-9-17/h6-13,15,21H,3-5,14H2,1-2H3,(H,24,25,27)/t21-/m1/s1
InChIKey
OXQNLLVUVDAEHC-OAQYLSRUSA-N
PubChem Compound ID
53347902
PubChem Substance ID
126700205, 131536831, 160686047, 160869999, 162066928, 163469046, 163563880, 210274805, 210280438, 223366001, 241377173, 249691292, 252158347, 252450204, 252479841
Target and Pathway
Target(s) Potassium voltage-gated channel subfamily KQT member 1 Target Info Activator [532012]
KEGG Pathway Adrenergic signaling in cardiomyocytes
Cholinergic synapse
Gastric acid secretion
Pancreatic secretion
Protein digestion and absorption
Vibrio cholerae infection
PathWhiz Pathway Muscle/Heart Contraction
Reactome Voltage gated Potassium channels
WikiPathways SIDS Susceptibility Pathways
Potassium Channels
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
TarBasePathway
References
Ref 542644(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7666).
Ref 532012Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5936-41.

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