Drug Information

Drug General Information
Drug ID
D07JDU
Former ID
DNC010166
Drug Name
SB-706375
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539372]
Formula
C20H22BrF3N2O5S
InChI
InChI=1S/C20H22BrF3N2O5S/c1-26-7-6-13(11-26)31-16-8-12(4-5-14(16)20(22,23)24)25-32(27,28)19-10-18(30-3)17(29-2)9-15(19)21/h4-5,8-10,13,25H,6-7,11H2,1-3H3/t13-/m1/s1
InChIKey
BPOWQJYAMDEAFF-CYBMUJFWSA-N
PubChem Compound ID
21023902
PubChem Substance ID
34729316, 103596982, 104103997, 119693274, 134347371, 135651016, 139078072, 143249079, 163625521, 172918562, 231620020, 241377113, 244307064, 249691250, 252158258
Target and Pathway
Target(s) Urotensin II receptor Target Info Inhibitor [530610]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 539372(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2165).
Ref 530610J Med Chem. 2010 Apr 8;53(7):2695-708.Urotensin-II receptor modulators as potential drugs.

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