Drug Information

Drug General Information
Drug ID
D0Y1MH
Former ID
DNC011663
Drug Name
2-(4-Hydroxy-phenyl)-8-methyl-3H-quinazolin-4-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534774]
Formula
C15H12N2O2
Canonical SMILES
CC1=CC=CC2=C1NC(=C3C=CC(=O)C=C3)NC2=O
InChI
1S/C15H12N2O2/c1-9-3-2-4-12-13(9)16-14(17-15(12)19)10-5-7-11(18)8-6-10/h2-8,16H,1H3,(H,17,19)
InChIKey
KKPXKVKVKPXXCO-UHFFFAOYSA-N
PubChem Compound ID
10491011
Target and Pathway
Target(s) Poly [ADP-ribose] polymerase-1 Target Info Inhibitor [534774]
KEGG Pathway Base excision repair
NF-kappa B signaling pathway
PANTHER Pathway FAS signaling pathway
Pathway Interaction Database Integrin-linked kinase signaling
Caspase Cascade in Apoptosis
Notch-mediated HES/HEY network
Reactome Dual Incision in GG-NER
WikiPathways FAS pathway and Stress induction of HSP regulation
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Nanoparticle triggered regulated necrosis
Corticotropin-releasing hormone
References
Ref 534774J Med Chem. 1998 Dec 17;41(26):5247-56.Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP).
Ref 534774J Med Chem. 1998 Dec 17;41(26):5247-56.Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP).

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