Drug Information

Drug General Information
Drug ID
D00TGC
Former ID
DIB020542
Drug Name
N-Me-aminopyrimidinone 9
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541068]
Formula
C16H21N3OS
InChI
InChI=1S/C16H21N3OS/c1-16(2,3)12-7-5-11(6-8-12)10-21-15-18-13(17)9-14(20)19(15)4/h5-9H,10,17H2,1-4H3
InChIKey
AJMIFZLEDTUBTN-UHFFFAOYSA-N
PubChem Compound ID
56951318
PubChem Substance ID
135658179, 136921628, 136966642, 178102359
Target and Pathway
Target(s) Voltage-gated sodium channel subunit alpha Nav1.7 Target Info Inhibitor (gating inhibitor) [531752]
Reactome Interaction between L1 and Ankyrins
References
Ref 541068(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5733).
Ref 531752Discovery and optimization of aminopyrimidinones as potent and state-dependent Nav1.7 antagonists. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1055-60.

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