Drug Information

Drug General Information
Drug ID
D07ZZG
Former ID
DIB019134
Drug Name
cicloprolol
Synonyms
SL 75-177-10
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540913]
Formula
C18H29NO4
InChI
InChI=1S/C18H29NO4/c1-14(2)19-11-16(20)13-23-18-7-5-17(6-8-18)22-10-9-21-12-15-3-4-15/h5-8,14-16,19-20H,3-4,9-13H2,1-2H3
InChIKey
JNDJPKHYZWRRIS-UHFFFAOYSA-N
PubChem Compound ID
146294
PubChem Substance ID
10249188, 15074408, 46223545, 50365851, 57346327, 85209381, 104413663, 125669932, 128299041, 135103884, 135164861, 135191792, 135650095, 162937256, 172866818, 179322145, 226934848, 241167483, 242549747
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Antagonist [525440]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 540913(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 552).
Ref 525440LK 204-545, a highly selective beta1-adrenoceptor antagonist at human beta-adrenoceptors. Eur J Pharmacol. 1999 Feb 19;367(2-3):431-5.

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