Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D01CXD
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| Former ID |
DNC008730
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| Drug Name |
9-(Aminomethyl)-9,10-dihydroanthracene
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| Synonyms |
C-(9,10-Dihydro-anthracen-9-yl)-methylamine
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [530331] | ||
| Formula |
C15H15N
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| Canonical SMILES |
C1C2=CC=CC=C2C(C3=CC=CC=C31)CN
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| InChI |
1S/C15H15N/c16-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)15/h1-8,15H,9-10,16H2
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| InChIKey |
GEICAQNIOJFRQN-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Histamine H1 receptor | Target Info | Inhibitor | [530331] | |
| 5-hydroxytryptamine 2A receptor | Target Info | Inhibitor | [525993] | ||
| WikiPathways | Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| IL-4 Signaling Pathway | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR ligand binding | |||||
| GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling | |||||
| Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | |||||
| SIDS Susceptibility Pathways | |||||
| GPCR downstream signaling | |||||
| GPCRs, Other | |||||
| References | |||||
| Ref 525993 | Bioorg Med Chem Lett. 2001 Feb 26;11(4):563-6.Exploring the relationship between binding modes of 9-(aminomethyl)-9,10-dihydroanthracene and cyproheptadine analogues at the 5-HT2A serotonin receptor. | ||||
| Ref 530331 | Bioorg Med Chem. 2009 Sep 15;17(18):6496-504. Epub 2009 Aug 13.Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity. | ||||
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