Drug Information

Drug General Information
Drug ID
D05AIT
Former ID
DNC010817
Drug Name
3-[6-(5-Chloro-2-thienyl)pyridin-2-yl]phenol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530868]
Formula
C15H10ClNOS
Canonical SMILES
C1=CC(=CC(=C1)O)C2=NC(=CC=C2)C3=CC=C(S3)Cl
InChI
1S/C15H10ClNOS/c16-15-8-7-14(19-15)13-6-2-5-12(17-13)10-3-1-4-11(18)9-10/h1-9,18H
InChIKey
IYXPXDBFKHBESO-UHFFFAOYSA-N
PubChem Compound ID
46887580
Target and Pathway
Target(s) Estradiol 17 beta-dehydrogenase 1 Target Info Inhibitor [530868]
BioCyc Pathway Superpathway of steroid hormone biosynthesis
Estradiol biosynthesis I
KEGG Pathway Steroid hormone biosynthesis
Metabolic pathways
Ovarian steroidogenesis
NetPath Pathway FSH Signaling Pathway
PANTHER Pathway Androgen/estrogene/progesterone biosynthesis
PathWhiz Pathway Androgen and Estrogen Metabolism
Reactome The canonical retinoid cycle in rods (twilight vision)
WikiPathways Steroid Biosynthesis
Metabolism of steroid hormones and vitamin D
Prostate Cancer
References
Ref 530868Bioorg Med Chem. 2010 May 15;18(10):3494-505. Epub 2010 Mar 29.Novel estrone mimetics with high 17beta-HSD1 inhibitory activity.
Ref 530868Bioorg Med Chem. 2010 May 15;18(10):3494-505. Epub 2010 Mar 29.Novel estrone mimetics with high 17beta-HSD1 inhibitory activity.

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