Target Information

Target General Infomation
Target ID
T23761
Former ID
TTDS00517
Target Name
Sarcoplasmic/endoplasmic reticulum calcium ATPase
Synonyms
ATP4; Ca(2+)-ATPase; Ca2+-ATPase; Calcium pump; Calcium-transporting ATPase; SERCA; SERCA pump; SR Ca(2+)-ATPase
Target Type
Successful
Disease Malaria [ICD10: B54]
BioChemical Class
Acid anhydrides hydrolase
Target Validation
T23761
EC Number
EC 3.6.3.8
Drugs and Mode of Action
Drug(s) Artemisinin Drug Info Approved Malaria [536602]
Artemisinin SP Drug Info Approved Malaria [536602]
Artesunate Drug Info Approved Malaria [536602]
Dihydroartemisinin Drug Info Approved Malaria [536602]
OZ277 Drug Info Approved Malaria [536602]
Piperaquine Drug Info Approved Malaria [536602]
Pyronaridine Drug Info Approved Malaria [551871]
Artesunate Drug Info Phase 2 Malaria [551871]
THAPSIGARGIN Drug Info Preclinical Discovery agent [540789], [545050]
Inhibitor Artemisinin Drug Info [536602]
Artemisinin SP Drug Info [536602]
Artesunate Drug Info [536602]
Cyclopiazonic acid Drug Info [535098]
Dihydroartemisinin Drug Info [536602]
OZ277 Drug Info [536602]
Piperaquine Drug Info [536602]
Pyronaridine Drug Info [536602]
THAPSIGARGIN Drug Info [531021]
Vanadate Drug Info [535098]
References
Ref 536602The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.
Ref 540789(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5351).
Ref 545050Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001971)
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 531021Bioorg Med Chem. 2010 Aug 1;18(15):5634-46. Epub 2010 Jun 16.Elucidation of the topography of the thapsigargin binding site in the sarco-endoplasmic calcium ATPase.
Ref 535098Expression and functional characterization of a Plasmodium falciparum Ca2+-ATPase (PfATP4) belonging to a subclass unique to apicomplexan organisms. J Biol Chem. 2001 Apr 6;276(14):10782-7. Epub 2001 Jan 5.
Ref 536602The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.

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