Target Information

Target General Infomation
Target ID
T94309
Former ID
TTDC00295
Target Name
Triacylglycerol lipase, pancreatic
Gene Name
PNLIP
Synonyms
PL; Pancreatic lipase; PNLIP
Target Type
Successful
Disease Bacterial infections [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10: A00-B99]
Cystic fibrosis [ICD9: 277; ICD10: E84]
Exocrine pancreatic insufficiency [ICD10: K86.8]
Obesity [ICD9: 278; ICD10: E66]
Pancreatic disease [ICD10: K85-K86]
BioChemical Class
Carboxylic ester hydrolase
Target Validation
T94309
UniProt ID
P16233
EC Number
EC 3.1.1.3
Sequence
MLPLWTLSLLLGAVAGKEVCYERLGCFSDDSPWSGITERPLHILPWSPKDVNTRFLLYTN
ENPNNFQEVAADSSSISGSNFKTNRKTRFIIHGFIDKGEENWLANVCKNLFKVESVNCIC
VDWKGGSRTGYTQASQNIRIVGAEVAYFVEFLQSAFGYSPSNVHVIGHSLGAHAAGEAGR
RTNGTIGRITGLDPAEPCFQGTPELVRLDPSDAKFVDVIHTDGAPIVPNLGFGMSQVVGH
LDFFPNGGVEMPGCKKNILSQIVDIDGIWEGTRDFAACNHLRSYKYYTDSIVNPDGFAGF
PCASYNVFTANKCFPCPSGGCPQMGHYADRYPGKTNDVGQKFYLDTGDASNFARWRYKVS
VTLSGKKVTGHILVSLFGNKGNSKQYEIFKGTLKPDSTHSNEFDSDVDVGDLQMVKFIWY
NNVINPTLPRVGASKIIVETNVGKQFNFCSPETVREEVLLTLTPC
Drugs and Mode of Action
Drug(s) Dalbavancin Drug Info Approved Bacterial infections [533123], [551871]
Orlistat Drug Info Approved Obesity [535886], [540740]
Pancrecarb Drug Info NDA filed Pancreatic disease [550604]
Liprotamase Drug Info Phase 3 Cystic fibrosis [522063]
MS-1819 Drug Info Phase 1/2 Exocrine pancreatic insufficiency [548921]
AZM-131 Drug Info Terminated Obesity [546516]
Inhibitor (Hydroxyethyloxy)Tri(Ethyloxy)Octane Drug Info [551393]
B-Nonylglucoside Drug Info [551374]
B-Octylglucoside Drug Info [551393]
Daio-Orengedokuto (DOT) Drug Info [535601]
Dalbavancin Drug Info [536589], [549974]
METHOXYUNDECYLPHOSPHINIC ACID Drug Info [551374]
Modulator AZM-131 Drug Info [550117]
Liprotamase Drug Info [549848]
MS-1819 Drug Info [550329]
Orlistat Drug Info [556264]
Pancrecarb Drug Info [550604]
Pathways
BioCyc Pathway Triacylglycerol degradation
Retinol biosynthesis
KEGG Pathway Glycerolipid metabolism
Metabolic pathways
Pancreatic secretion
Fat digestion and absorption
Vitamin digestion and absorption
Reactome Retinoid metabolism and transport
WikiPathways Visual phototransduction
Lipid digestion, mobilization, and transport
References
Ref 522063ClinicalTrials.gov (NCT00500084) Phase III ALTU-135 CP Safety Trial. U.S. National Institutes of Health.
Ref 5331232014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
Ref 535886Obesity and pharmacologic therapy. Endocrinol Metab Clin North Am. 2003 Dec;32(4):1005-24.
Ref 540740(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5277).
Ref 546516Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008694)
Ref 548921Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030334)
Ref 550604Clinical pipeline report, company report or official report of Digestive Care.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 535601Daio-Orengedokuto inhibits HMG-CoA reductase and pancreatic lipase. Biol Pharm Bull. 2002 Nov;25(11):1442-5.
Ref 536589Dalbavancin: a novel once-weekly lipoglycopeptide antibiotic. Clin Infect Dis. 2008 Feb 15;46(4):577-83.
Ref 549848Clinical pipeline report, company report or official report of Anthera Pharmaceuticals.
Ref 549974Pfizer. Product Development Pipeline. March 31 2009.
Ref 550117US patent application no. 7217,697, Glucopyranosyloxypyrazole derivative medicinal composition containing the same medicinal use thereof and intermediate therefor.
Ref 550329Clinical pipeline report, company report or official report of AzurRx.
Ref 550604Clinical pipeline report, company report or official report of Digestive Care.
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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