Resistance mutation info of target

Target General Information
Target ID T40016
Target Name Glucocorticoid receptor (NR3C1) Target Info
Gene Name NR3C1
Species Homo sapiens
Uniprot ID GCR_HUMAN
Sequence MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRR
LLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLK
LLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGN
VKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGN
SNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTV
YCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVG
SENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKL
CLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRK
CLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIE
PEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSW
MFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSY
EEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTK
LLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK [H
omo sapiens]
Drug Resistance Mutation and Corresponding Drugs
Ref 1572605The ChEMBL database in 2017.
Mutation Info Missense: L672P
Drugs
Drug Name Generalized glucocorticoid Drug Info [1559271]
Targeted Disease Adrenal incidentalomas
Mutation Info Missense: R477S
Drugs
Drug Name Generalized glucocorticoid Drug Info [1559271]
Targeted Disease Adrenal incidentalomas
Mutation Info Missense: Y478C
Drugs
Drug Name Generalized glucocorticoid Drug Info [1559271]
Targeted Disease Adrenal incidentalomas
Reference
Ref 1559271Three Novel Heterozygous Point Mutations of NR3C1 Causing Glucocorticoid Resistance.Hum Mutat.2016 Aug;37(8):794-803.

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