Drug Information

Drug General Information
Drug ID
D0ZZ4Z
Former ID
DNC005857
Drug Name
3-(2-Pyrrolidin-1-yl-ethyl)-1H-indol-4-ol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527668]
Formula
C14H18N2O
Canonical SMILES
C1CCN(C1)CCC2=CNC3=C2C(=CC=C3)O
InChI
1S/C14H18N2O/c17-13-5-3-4-12-14(13)11(10-15-12)6-9-16-7-1-2-8-16/h3-5,10,15,17H,1-2,6-9H2
InChIKey
XASLPZWIPBCAPF-UHFFFAOYSA-N
PubChem Compound ID
21854226
Target and Pathway
Target(s) 5-hydroxytryptamine 2C receptor Target Info Inhibitor [527668]
5-hydroxytryptamine 2A receptor Target Info Inhibitor [527668]
5-hydroxytryptamine 2B receptor Target Info Inhibitor [527668]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
SIDS Susceptibility Pathways
GPCR downstream signaling
GPCRs, OtherWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
References
Ref 527668Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9.SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist.
Ref 527668Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9.SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.