Drug Information

Drug General Information
Drug ID
D0Z6TG
Drug Name
ZD-6021
Synonyms
ZD-6021; 255049-08-2; ZD-6021
Drug Type
Small molecular drug
Indication Unspecified Investigative [1559815], [1560297]
Formula
C35H35Cl2N3O2S
PubChem Compound ID
9895516
Target and Pathway
Target(s) Substance-P receptor Target Info Modulator
NK-2 receptor Target Info Modulator
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Measleshsa04020:Calcium signaling pathway
PANTHER Pathway CCKR signaling map ST
Reactome G alpha (q) signalling eventsR-HSA-416476:G alpha (q) signalling events
WikiPathways SIDS Susceptibility Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP2664:Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signaling
References
Ref 1559815Molecular cloning, mutations and effects of NK1 receptor antagonists reveal the human-like pharmacology of gerbil NK1 receptors.Biochem Pharmacol.2007 Jan 15;73(2):259-69.
Ref 1560297Pharmacological characterization of ZD6021: a novel, orally active antagonist of the tachykinin receptors.

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