Drug Information

Drug General Information
Drug ID
D0Z3NO
Former ID
DIB018290
Drug Name
[3H]fananserin
Synonyms
[3H]RP62203; [3H]RP-62203
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540204]
Formula
C23H24FN3O2S
InChI
InChI=1S/C23H24FN3O2S/c24-19-8-10-20(11-9-19)26-16-14-25(15-17-26)12-3-13-27-21-6-1-4-18-5-2-7-22(23(18)21)30(27,28)29/h1-2,4-11H,3,12-17H2
InChIKey
VGIGHGMPMUCLIQ-UHFFFAOYSA-N
PubChem Compound ID
60785
PubChem Substance ID
8187052, 14856245, 43118132, 47205811, 50064308, 50112947, 57314111, 78566174, 85212007, 85788217, 103922972, 104321638, 129471014, 134339513, 135018988, 135698206, 137237442, 140010545, 140173976, 144206140, 160703995, 162023484, 163124146, 170466120, 178100286, 178102086, 179149761, 198976575, 204372620, 224932293, 226676066, 241376050, 249617645, 250071166, 252156679
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Antagonist [534046]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 540204(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3229).
Ref 534046Autoradiographic studies of RP 62203, a potent 5-HT2 receptor antagonist. Pharmacological characterization of [3H]RP 62203 binding in the rat brain. Eur J Pharmacol. 1993 Mar 16;233(1):37-45.

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