Drug Information

Drug General Information
Drug ID
D0Z2UW
Former ID
DIB012160
Drug Name
Nicaraven
Synonyms
AVS; Antevan; Antevas
Drug Type
Small molecular drug
Indication Cerebrovascular disorders [ICD10:I60-I69] Phase 3 [528516]
Company
Chugai Pharmaceutical
Formula
C15H16N4O2
Canonical SMILES
C(=O)(c1cnccc1)NC(CNC(=O)c1cnccc1)C
CAS Number
CAS 79455-30-4
PubChem Compound ID
71234
Target and Pathway
Target(s) Poly [ADP-ribose] polymerase-1 Target Info Modulator [528516]
KEGG Pathway Base excision repair
NF-kappa B signaling pathway
PANTHER Pathway FAS signaling pathway
Pathway Interaction Database Integrin-linked kinase signaling
Caspase Cascade in Apoptosis
Notch-mediated HES/HEY network
Reactome Dual Incision in GG-NER
WikiPathways FAS pathway and Stress induction of HSP regulation
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Nanoparticle triggered regulated necrosis
Corticotropin-releasing hormone
References
Ref 528516Inhibition of poly (ADP-ribose) polymerase as a protective effect of nicaraven in ionizing radiation- and ara-C-induced cell death. Anticancer Res. 2006 Sep-Oct;26(5A):3421-7.
Ref 528516Inhibition of poly (ADP-ribose) polymerase as a protective effect of nicaraven in ionizing radiation- and ara-C-induced cell death. Anticancer Res. 2006 Sep-Oct;26(5A):3421-7.

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