Drug Information

Drug General Information
Drug ID
D0Z0KY
Former ID
DIB019962
Drug Name
GSK494581A
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540940]
Formula
C27H28F2N2O4S
InChI
InChI=1S/C27H28F2N2O4S/c1-18(35-2)20-6-11-26(25(29)16-20)30-12-14-31(15-13-30)27(32)24-17-22(36(3,33)34)9-10-23(24)19-4-7-21(28)8-5-19/h4-11,16-18H,12-15H2,1-3H3
InChIKey
JQXZHDOSMUZLML-UHFFFAOYSA-N
PubChem Compound ID
11855860
PubChem Substance ID
17168588, 23909944, 30178310, 78266418, 141824892, 178102200, 230820596, 246411671
Target and Pathway
Target(s) G-protein coupled receptor 55 Target Info Agonist [531335]
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 540940(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5562).
Ref 531335Pharmacology of GPR55 in yeast and identification of GSK494581A as a mixed-activity glycine transporter subtype 1 inhibitor and GPR55 agonist. J Pharmacol Exp Ther. 2011 Apr;337(1):236-46.

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