Drug Information

Drug General Information
Drug ID
D0YD9E
Former ID
DIB006988
Drug Name
PF-00212062
Synonyms
EP2 antagonists, Pfizer; PF-00212062; PF-04852946
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Investigative [543187]
Company
Pfizer Inc
Formula
C27H24N2O5
InChI
InChI=1S/C27H24N2O5/c1-33-23-10-8-22(9-11-23)25(30)29-15-14-27(17-29,26(31)32)18-34-24-12-6-21(7-13-24)20-4-2-19(16-28)3-5-20/h2-13H,14-15,17-18H2,1H3,(H,31,32)
InChIKey
MDVYCLAYSVNYDS-UHFFFAOYSA-N
PubChem Compound ID
46213069
PubChem Substance ID
96067435, 120477927, 140778909, 224385591, 228544619, 244498061, 252166740
Target and Pathway
Target(s) Prostaglandin E2receptor, EP2 subtype Target Info Antagonist [543778]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
Renin secretion
Pathways in cancer
Reactome Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Ovarian Infertility Genes
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 543187(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8538).
Ref 543778(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 341).

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