Drug Information

Drug General Information
Drug ID
D0Y5ZT
Former ID
DIB013290
Drug Name
KRP-203
Synonyms
KNF-299; KRP-203-P prodrug, Kyorin
Drug Type
Small molecular drug
Indication Cutaneous lupus erythematosus [ICD9: 710; ICD10:M32] Phase 2 [523356]
Company
Kyorin Pharmaceutical Co Ltd
Formula
C24H26ClNO3S
Canonical SMILES
NC(CO)(CCc1ccc(Sc2cccc(OCc3ccccc3)c2)cc1Cl)CO.Cl
CAS Number
CAS 509088-69-1
PubChem Compound ID
11155874
Target and Pathway
Target(s) Sphingosine 1-phosphate receptor 1 Target Info Agonist [532341], [532456]
KEGG Pathway FoxO signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
IL2 Signaling Pathway
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
S1P3 pathway
S1P1 pathway
Sphingosine 1-phosphate (S1P) pathway
PDGFR-beta signaling pathway
Reactome G alpha (i) signalling events
Lysosphingolipid and LPA receptors
WikiPathways Signal Transduction of S1P Receptor
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 523356ClinicalTrials.gov (NCT01294774) Safety and Efficacy of KRP203 in Subacute Cutaneous Lupus Erythematosus. U.S. National Institutes of Health.
Ref 532341KRP-203, sphingosine 1-phosphate receptor type 1 agonist, ameliorates atherosclerosis in LDL-R-/- mice. Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1505-12.
Ref 532456Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond. Nat Rev Drug Discov. 2013 Sep;12(9):688-702.

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