Drug Information

Drug General Information
Drug ID
D0Y1VB
Former ID
DIB021174
Drug Name
VU0152099
Synonyms
3-amino-N-(benzo[d][1,3]dioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine carboxamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540226]
Formula
C18H17N3O3S
InChI
InChI=1S/C18H17N3O3S/c1-9-5-10(2)21-18-14(9)15(19)16(25-18)17(22)20-7-11-3-4-12-13(6-11)24-8-23-12/h3-6H,7-8,19H2,1-2H3,(H,20,22)
InChIKey
AZOGCTMOKNTHIU-UHFFFAOYSA-N
PubChem Compound ID
1541501
PubChem Substance ID
1906324, 5387196, 8651744, 32244337, 48385919, 49691903, 53375923, 57849696, 81105920, 85163689, 87932948, 106717433, 110510269, 117418403, 125945534, 170070772, 172668416, 178100299, 252628342
Target and Pathway
Target(s) Muscarinic receptor Target Info Modulator (allosteric modulator) [529671]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
PathWhiz Pathway Muscle/Heart Contraction
Reactome Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 540226(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3256).
Ref 529671Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats. J Pharmacol Exp Ther. 2008 Dec;327(3):941-53.

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