Drug Information

Drug General Information
Drug ID
D0X7EG
Former ID
DIB005583
Drug Name
OC-000459
Synonyms
OC-1768; OC-2125; OC-2184; OC-459; OC-499; ODC-9101; CRTH2 antagonists (asthma/allergy), Oxagen
Drug Type
Small molecular drug
Indication Allergy [ICD9: 995.3; ICD10:T78.4] Phase 2 [522929]
Company
Oxagen Ltd
Formula
C21H17FN2O2
Canonical SMILES
c1c(cc2c(c1)n(c(c2Cc1ccc2c(n1)cccc2)C)CC(=O)O)F
PubChem Compound ID
11462174
Target and Pathway
Target(s) Putative G-protein coupled receptor 44 Target Info Antagonist [532216]
Reactome Prostanoid ligand receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 522929ClinicalTrials.gov (NCT01056783) Proof of Concept Study of OC000459 in Eosinophilic Esophagitis. U.S. National Institutes of Health.
Ref 532216Anti-eosinophil activity and clinical efficacy of the CRTH2 antagonist OC000459 in eosinophilic esophagitis. Allergy. 2013 Mar;68(3):375-85.

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