Drug Information

Drug General Information
Drug ID
D0X6OV
Former ID
DIB021070
Drug Name
toxaphene
Synonyms
octachlorocamphene
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539872]
Formula
C10H8Cl8
InChI
InChI=1S/C10H8Cl8/c1-4-7(2-11,3-12)9(16)6(14)5(13)8(4,15)10(9,17)18/h5-6H,1-3H2
InChIKey
OEJNXTAZZBRGDN-UHFFFAOYSA-N
PubChem Compound ID
5284469
PubChem Substance ID
17389704, 29157103, 39317800, 48414557, 48421768, 48424195, 48425693, 57359078, 78747868, 113862954, 124891500, 124891501, 135650755, 136077376, 137171673, 144204724, 144208110, 162224237, 180422974, 231707701, 242362134
Target and Pathway
Target(s) Steroid hormone receptor ERR1 Target Info Antagonist [525591]
Reactome PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Nuclear Receptor transcription pathway
WikiPathways Mitochondrial Gene Expression
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Nuclear Receptors
References
Ref 539872(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2830).
Ref 525591Two organochlorine pesticides, toxaphene and chlordane, are antagonists for estrogen-related receptor alpha-1 orphan receptor. Cancer Res. 1999 Sep 15;59(18):4519-24.

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