Drug Information

Drug General Information
Drug ID
D0X5OV
Former ID
DIB008203
Drug Name
TTA-A8
Synonyms
TTA-A2; TTA-P2; T-type calcium channel antagonists, Merck & Co
Drug Type
Small molecular drug
Indication Insomnia [ICD9: 307.41, 307.42, 327.0, 780.51, 780.52; ICD10:F51.0, G47.0] Preclinical [542695], [546748]
Company
Merck & Co Inc
Formula
C20H21F3N2O2
InChI
InChI=1S/C20H21F3N2O2/c1-13(18-9-8-17(11-24-18)27-12-20(21,22)23)25-19(26)10-14-2-4-15(5-3-14)16-6-7-16/h2-5,8-9,11,13,16H,6-7,10,12H2,1H3,(H,25,26)/t13-/m1/s1
InChIKey
GEYDMBNDOVPFJL-CYBMUJFWSA-N
PubChem Compound ID
53317097
PubChem Substance ID
124957021, 125088269, 137985283, 223366057, 233761524, 247592261
Target and Pathway
Target(s) Voltage-dependent T-type calcium channel subunit alpha-1H Target Info Antagonist [532802]
KEGG Pathway MAPK signaling pathway
Calcium signaling pathway
Circadian entrainment
PathWhiz Pathway Muscle/Heart Contraction
Reactome NCAM1 interactions
WikiPathways Corticotropin-releasing hormone
NCAM signaling for neurite out-growth
References
Ref 542695(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7724).
Ref 546748Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010094)
Ref 532802Short-acting T-type calcium channel antagonists significantly modify sleep architecture in rodents. ACS Med Chem Lett. 2010 Aug 24;1(9):504-9.

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