Drug Information

Drug General Information
Drug ID
D0X4MC
Former ID
DCL000043
Drug Name
AMG 076
Drug Type
Small molecular drug
Indication Obesity [ICD9: 278; ICD10:E66] Discontinued in Phase 1 [547852]
Company
Amgen
Formula
C26H33F3N2O2
Canonical SMILES
CC1C2CN(CCC2CC3=C1C4=C(N3)C=CC(=C4)C(F)(F)F)CCC5(CCCCC5<br />)C(=O)O
InChI
1S/C26H33F3N2O2/c1-16-20-15-31(12-10-25(24(32)33)8-3-2-4-9-25)11-7-17(20)13-22-23(16)19-14-18(26(27,28)29)5-6-21(19)30-22/h5-6,14,16-17,20,30H,2-4,7-13,15H2,1H3,(H,32,33)/t16-,17-,20-/m1/s1
InChIKey
WAOZNBXSEVIAGX-MBOZVWFJSA-N
PubChem Compound ID
10004545
PubChem Substance ID
14984406, 22438515, 44096655, 77472888, 134338749, 139798343, 160673377, 160862605, 163642539, 198937626, 228826706, 247063118
ChEBI ID
ChEBI:43362
Target and Pathway
Target(s) Melanin-concentrating hormone receptor 1 Target Info Antagonist [536531]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 547852Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019931)
Ref 536531Stereoselective synthesis of a MCHr1 antagonist. J Org Chem. 2007 Dec 7;72(25):9648-55. Epub 2007 Nov 13.

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