Drug Information

Drug General Information
Drug ID
D0X4CI
Former ID
DNC005187
Drug Name
2,3,4,5-Tetrabromo-6-(2,4-dibromo-phenoxy)-phenol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527145]
Formula
C12H4Br6O2
Canonical SMILES
C1=CC(=C(C=C1Br)Br)OC2=C(C(=C(C(=C2Br)Br)Br)Br)O
InChI
1S/C12H4Br6O2/c13-4-1-2-6(5(14)3-4)20-12-10(18)8(16)7(15)9(17)11(12)19/h1-3,19H
InChIKey
LDMKXEGTHGJWLG-UHFFFAOYSA-N
PubChem Compound ID
9986835
Target and Pathway
Target(s) Arachidonate 15-lipoxygenase Target Info Inhibitor [527145]
Arachidonate 12-lipoxygenase, 12S-type Target Info Inhibitor [527145]
BioCyc Pathway Resolvin D biosynthesis
Lipoxin biosynthesisPWY66-392:Lipoxin biosynthesis
KEGG Pathway Arachidonic acid metabolism
Linoleic acid metabolism
Metabolic pathways
Serotonergic synapsehsa00590:Arachidonic acid metabolism
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
NetPath Pathway IL4 Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathwayP00031:Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database IL4-mediated signaling events
PathWhiz Pathway Arachidonic Acid MetabolismPW000044:Arachidonic Acid Metabolism
WikiPathways Arachidonic acid metabolism
Eicosanoid SynthesisWP2650:Arachidonic acid metabolism
Eicosanoid Synthesis
References
Ref 527145J Med Chem. 2004 Jul 29;47(16):4060-5.Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase.
Ref 527145J Med Chem. 2004 Jul 29;47(16):4060-5.Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase.

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