Drug Information

Drug General Information
Drug ID
D0X3KX
Former ID
DIB007522
Drug Name
U-80816
Indication Amnesia [ICD10:F04] Terminated [544857]
Company
Pharmacia & Upjohn Co
Canonical SMILES
n1(c(ccc1)C)CC#CCN1C(=O)CCC1
CAS Number
CAS 138554-11-7
Target and Pathway
Target(s) Muscarinic receptor Target Info Modulator [550027]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
PathWhiz Pathway Muscle/Heart Contraction
Reactome Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 544857Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001336)
Ref 550027U-80816: A novel partial muscarinic agonist. Drug Development Research Volume 24, Issue 1, pages 53-66, 1991.

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