TTD | Drug: D0X2ZW

Drug General Information
Drug ID	D0X2ZW
Former ID	DIB020041
Drug Name	IKs124
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[539669]
Formula	C18H26N2O3S
InChI	InChI=1S/C18H26N2O3S/c1-5-7-10-20(24(21,22)6-2)16-12-18(3,4)23-17-9-8-14(13-19)11-15(16)17/h8-9,11,16H,5-7,10,12H2,1-4H3
InChIKey	VTICUGOJGKDYJD-UHFFFAOYSA-N
PubChem Compound ID	15338746
PubChem Substance ID	54167469, 129524022, 135650376, 232269312
Target and Pathway
Target(s)	Potassium voltage-gated channel subfamily KQT member 1	Target Info	Blocker (channel blocker)	[527319]
KEGG Pathway	Adrenergic signaling in cardiomyocytes
	Cholinergic synapse
	Gastric acid secretion
	Pancreatic secretion
	Protein digestion and absorption
	Vibrio cholerae infection
PathWhiz Pathway	Muscle/Heart Contraction
Reactome	Voltage gated Potassium channels
WikiPathways	SIDS Susceptibility Pathways
	Potassium Channels
	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in lymphocytes - TarBase
	TarBasePathway
References
Ref 539669	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2591).
Ref 527319	Heteromeric KCNE2/KCNQ1 potassium channels in the luminal membrane of gastric parietal cells. J Physiol. 2004 Dec 1;561(Pt 2):547-57. Epub 2004 Oct 7.

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Drug Information