TTD | Drug: D0W9OR

Drug General Information
Drug ID	D0W9OR
Former ID	DAP001334
Drug Name	OspA lipoprotein
Drug Type	Vaccine
Indication	Lyme disease [ICD9: 88.81; ICD10:A69.2]		Approved	[536381]
Therapeutic Class	Vaccines
Formula	C1198H2012N322O422S2
Target and Pathway
Target(s)	B-cell receptor CD22	Target Info	Binder	[534840]
KEGG Pathway	Cell adhesion molecules (CAMs)
	Hematopoietic cell lineage
	B cell receptor signaling pathway
PANTHER Pathway	B cell activation
Pathway Interaction Database	BCR signaling pathway
Reactome	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Reactome	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
WikiPathways	B Cell Receptor Signaling Pathway
References
Ref 536381	Infection of mice with lyme disease spirochetes constitutively producing outer surface proteins a and B. Infect Immun. 2007 Jun;75(6):2786-94. Epub 2007 Mar 19.
Ref 534840	Safety and immunogenicity of recombinant Bacille Calmette-Gu?\|rin (rBCG) expressing Borrelia burgdorferi outer surface protein A (OspA) lipoprotein in adult volunteers: a candidate Lyme disease vaccine. Vaccine. 1999 Feb 26;17(7-8):904-14.

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Drug Information