TTD | Drug: D0W4UQ

Drug General Information
Drug ID	D0W4UQ
Former ID	DNC010329
Drug Name	(Z)-5-Amino-3-(4-methoxybenzylidene)indolin-2-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530673]
Formula	C16H14N2O2
Canonical SMILES	COC1=CC=C(C=C1)C=C2C3=C(C=CC(=C3)N)NC2=O
InChI	1S/C16H14N2O2/c1-20-12-5-2-10(3-6-12)8-14-13-9-11(17)4-7-15(13)18-16(14)19/h2-9H,17H2,1H3,(H,18,19)/b14-8-
InChIKey	DYCBCUFDDRQCID-ZSOIEALJSA-N
PubChem Compound ID	46233144
Target and Pathway
Target(s)	Proto-oncogene tyrosine-protein kinase receptor ret	Target Info	Inhibitor	[530673]
KEGG Pathway	Endocytosis
	Pathways in cancer
	Thyroid cancer
	Central carbon metabolism in cancer
Pathway Interaction Database	Signaling events regulated by Ret tyrosine kinase
Pathway Interaction Database	Posttranslational regulation of adherens junction stability and dissassembly
WikiPathways	SIDS Susceptibility Pathways
WikiPathways	Dopaminergic Neurogenesis
References
Ref 530673	Bioorg Med Chem. 2010 Feb 15;18(4):1482-96. Epub 2010 Jan 11.Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors.
Ref 530673	Bioorg Med Chem. 2010 Feb 15;18(4):1482-96. Epub 2010 Jan 11.Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors.

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Drug Information