Drug Information

Drug General Information
Drug ID
D0W3UH
Former ID
DIB002831
Drug Name
QLT-091568
Synonyms
OT-730; Beta adrenoceptor antagonist prodrug (glaucoma/ocular hypertension), Othera
Indication Glaucoma [ICD9: 365; ICD10:H40-H42] Phase 1/2 [522437]
Company
Othera Pharmaceuticals Inc
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Antagonist [551556]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 522437ClinicalTrials.gov (NCT00753168) Phase 1-2 Evaluation of OT-730 Eye Drops in Reducing the Intraocular Pressure in Patients With Ocular Hypertension or Open-Angle Glaucoma. U.S. National Institutes ofHealth.
Ref 551556Clinical pipeline report, company report or official report of QLT Inc.

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