Drug Information

Drug General Information
Drug ID
D0W3BA
Former ID
DIB003305
Drug Name
Methanesulfonyl fluoride
Synonyms
Fluoride; Methanesulfonyl fluoride (oral, Alzheimer's disease/cognitive disorder)
Drug Type
Small molecular drug
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Phase 2 [549186]
Company
University of Texas
Formula
CH3FO2S
Canonical SMILES
S(=O)(=O)(F)C
PubChem Compound ID
11207
Target and Pathway
Target(s) Acetylcholinesterase Target Info Inhibitor [532098]
KEGG Pathway Glycerophospholipid metabolism
Cholinergic synapse
PANTHER Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database ATF-2 transcription factor network
PathWhiz Pathway Phospholipid Biosynthesis
WikiPathways Monoamine Transport
Biogenic Amine Synthesis
Acetylcholine Synthesis
Integrated Pancreatic Cancer Pathway
References
Ref 549186Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033430)
Ref 532098A randomized phase I study of methanesulfonyl fluoride, an irreversible cholinesterase inhibitor, for the treatment of Alzheimer's disease. Br J Clin Pharmacol. 2013 May;75(5):1231-9.

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