Drug Information

Drug General Information
Drug ID
D0W1ZW
Former ID
DIB021162
Drug Name
VPC03090-P
Synonyms
VPC-03090-P; VPC 03090-P
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542021]
Formula
C19H32NO4P
InChI
InChI=1S/C19H32NO4P/c1-2-3-4-5-6-7-9-16-10-8-11-17(12-16)18-13-19(20,14-18)15-24-25(21,22)23/h8,10-12,18H,2-7,9,13-15,20H2,1H3,(H2,21,22,23)
InChIKey
LNMFICMTNRORPU-UHFFFAOYSA-N
PubChem Compound ID
73755254
PubChem Substance ID
178103571
Target and Pathway
Target(s) Sphingosine 1-phosphate receptor 1 Target Info Antagonist [531499]
S1P4 receptor Target Info Agonist [531499]
Sphingosine-1-phosphate receptor-3 Target Info Antagonist [531499]
Sphingosine 1-phosphate receptor 5 Target Info Agonist [531499]
KEGG Pathway FoxO signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interactionhsa04071:Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
IL2 Signaling Pathway
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
S1P3 pathway
S1P1 pathway
Sphingosine 1-phosphate (S1P) pathway
PDGFR-beta signaling pathways1p_s1p3_pathway:S1P3 pathway
Sphingosine 1-phosphate (S1P) pathways1p_s1p4_pathway:S1P4 pathway
S1P5 pathway
Reactome G alpha (i) signalling events
Lysosphingolipid and LPA receptorsR-HSA-418594:G alpha (i) signalling events
Lysosphingolipid and LPA receptors
WikiPathways Signal Transduction of S1P Receptor
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP26:Signal Transduction of S1P Receptor
GPCR downstream signalingWP26:Signal Transduction of S1P Receptor
References
Ref 542021(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6992).
Ref 531499Characterization of a sphingosine 1-phosphate receptor antagonist prodrug. J Pharmacol Exp Ther. 2011 Sep;338(3):879-89.

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