Drug Information

Drug General Information
Drug ID
D0V8VY
Former ID
DNC004761
Drug Name
2-Pyrrolidin-1-yl-benzo[h]chromen-4-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527386]
Formula
C17H15NO2
Canonical SMILES
C1CCN(C1)C2=CC(=O)C3=C(O2)C4=CC=CC=C4C=C3
InChI
1S/C17H15NO2/c19-15-11-16(18-9-3-4-10-18)20-17-13-6-2-1-5-12(13)7-8-14(15)17/h1-2,5-8,11H,3-4,9-10H2
InChIKey
CYNBNMZZLAYOIM-UHFFFAOYSA-N
PubChem Compound ID
3045696
Target and Pathway
Target(s) DNA-dependent protein kinase catalytic subunit Target Info Inhibitor [527386]
KEGG Pathway Non-homologous end-joining
Cell cycle
NetPath Pathway IL1 Signaling Pathway
Pathway Interaction Database DNA-PK pathway in nonhomologous end joining
Coregulation of Androgen receptor activity
Class I PI3K signaling events mediated by Akt
BARD1 signaling events
Reactome Nonhomologous End-Joining (NHEJ)
WikiPathways DNA Damage Response
Non-homologous end joining
FAS pathway and Stress induction of HSP regulation
Cytosolic sensors of pathogen-associated DNA
Retinoblastoma (RB) in Cancer
Prostate Cancer
Double-Strand Break Repair
Cell Cycle
miRNA Regulation of DNA Damage Response
References
Ref 527386J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
Ref 527386J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.

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