Drug Information

Drug General Information
Drug ID
D0V2YJ
Former ID
DIB002509
Drug Name
MK-0731
Synonyms
C-4251; MK-731
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 1 [521631]
Company
Merck & Co Inc
Formula
C25H28F3N3O2
Canonical SMILES
c1(C2=C[C@](c3ccccc3)(CO)N(C(=O)N([C@H]3CCN(C[C@H]3F)C)<br />C)C2)c(ccc(c1)F)F
PubChem Compound ID
11655511
Target and Pathway
Target(s) Kinesin-like protein KIF11 Target Info Inhibitor [531974]
Reactome MHC class II antigen presentation
Kinesins
WikiPathways MHC class II antigen presentation
Kinesins
References
Ref 521631ClinicalTrials.gov (NCT00104364) A Study of MK0731 in Patients With Advanced Solid Tumors (0731-002)(COMPLETED). U.S. National Institutes of Health.
Ref 531974Kinesins and cancer. Nat Rev Cancer. 2012 Jul 24;12(8):527-39.

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