Drug Information

Drug General Information
Drug ID
D0U7UY
Former ID
DIB019101
Drug Name
CEP-1374
Synonyms
KT7515; CEP1374; CEP 1374
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526038]
Formula
C33H33N3O5S2
InChI
InChI=1S/C33H33N3O5S2/c1-5-42-15-17-7-9-22-19(11-17)26-27-21(14-34-30(27)37)25-20-12-18(16-43-6-2)8-10-23(20)36-29(25)28(26)35(22)24-13-33(39,31(38)40-4)32(36,3)41-24/h7-12,24,39H,5-6,13-16H2,1-4H3,(H,34,37)/t24-,32+,33+/m1/s1
InChIKey
SCMLRESZJCKCTC-KMYQRJGFSA-N
PubChem Compound ID
9917013
PubChem Substance ID
14887503, 14936433, 45988662, 56269893, 75310112, 103211632, 142182698, 179150011, 237164836, 241377255, 245423735, 249565853, 249691341, 252158473
Target and Pathway
Target(s) Mitogen-activated protein kinase kinase kinase 10 Target Info Inhibitor [526038]
Mitogen-activated protein kinase kinase kinase 9 Target Info Inhibitor [526038]
Mitogen-activated protein kinase kinase kinase 11 Target Info Inhibitor [526038]
KEGG Pathway MAPK signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
PANTHER Pathway Huntington disease
p38 MAPK pathwayP06959:CCKR signaling map ST
Pathway Interaction Database p38 MAPK signaling pathwayreelinpathway:Reelin signaling pathway
CDC42 signaling events
IFN-gamma pathway
RAC1 signaling pathway
WikiPathways Insulin SignalingWP481:Insulin Signaling
p38 MAPK Signaling Pathway
References
Ref 526038Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family. J Biol Chem. 2001 Jul 6;276(27):25302-8. Epub 2001 Apr 26.
Ref 526038Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family. J Biol Chem. 2001 Jul 6;276(27):25302-8. Epub 2001 Apr 26.

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