Drug Information

Drug General Information
Drug ID
D0U3WK
Former ID
DIB020918
Drug Name
SB452533
Synonyms
SB-452533; SB 452533
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467649]
Formula
C18H22BrN3O
InChI
InChI=1S/C18H22BrN3O/c1-3-22(15-8-6-7-14(2)13-15)12-11-20-18(23)21-17-10-5-4-9-16(17)19/h4-10,13H,3,11-12H2,1-2H3,(H2,20,21,23)
InChIKey
IFJYEGJUQIBBQV-UHFFFAOYSA-N
PubChem Compound ID
9842609
PubChem Substance ID
14804329, 24140520, 44940683, 49688542, 75676188, 103349244, 141108901, 143120792, 178101127, 223866881, 232425736, 241376347, 245829903, 249617806, 252157142
Target and Pathway
Target(s) Vanilloid receptor 1 Target Info Blocker (channel blocker) [543861]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome TRP channels
References
Ref 467649(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4310).
Ref 543861(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 507).

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