Drug Information

Drug General Information
Drug ID
D0U2XU
Former ID
DNCL002657
Drug Name
XEN-2174
Indication Cancer pain [ICD9: 140-229, 338,780; ICD10:R52, G89] Phase 2 [548033]
Company
Xenome
Target and Pathway
Target(s) Sodium-dependent noradrenaline transporter Target Info Inhibitor [527387]
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 548033Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021315)
Ref 527387Spinal noradrenaline transporter inhibition by reboxetine and Xen2174 reduces tactile hypersensitivity after surgery in rats. Pain. 2005 Feb;113(3):271-6.

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