Drug Information

Drug General Information
Drug ID
D0TS8E
Former ID
DNCL003146
Drug Name
ADX71149
Indication Psychiatric disorder [ICD9: 290-319; ICD10:F01-F99] Discontinued in Phase 2 [548928]
Company
Addex Pharmaceuticals; Johnson & Johnson Pharmaceutical
Target and Pathway
Target(s) Metabotropic glutamate receptor 2 Target Info Modulator [551580]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Cocaine addiction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group II pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signaling
References
Ref 548928Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030424)
Ref 551580MGlu2 receptor-mediated modulation of conditioned avoidance behavior in rats. European journal of pharmacology. 01/2014; 727(1).

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