Drug Information

Drug General Information
Drug ID
D0TJ7R
Former ID
DNC007496
Drug Name
1-benzyl-4-phenylpiperidin-4-ol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528785]
Formula
C18H21NO
Canonical SMILES
C1CN(CCC1(C2=CC=CC=C2)O)CC3=CC=CC=C3
InChI
1S/C18H21NO/c20-18(17-9-5-2-6-10-17)11-13-19(14-12-18)15-16-7-3-1-4-8-16/h1-10,20H,11-15H2
InChIKey
FCLMXEAPEVBCKQ-UHFFFAOYSA-N
PubChem Compound ID
97333
Target and Pathway
Target(s) Nociceptin receptor Target Info Inhibitor [528785]
KEGG Pathway Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 528785Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1.
Ref 528785Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1.

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