Drug Information

Drug General Information
Drug ID
D0TC5E
Former ID
DIB018567
Drug Name
2-methylhistamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538783]
Formula
C7H15N3O3S
InChI
InChI=1S/C7H15N3O3S/c11-2-1-8-3-9(5-12)7(14)10(4-8)6-13/h11-13H,1-6H2
InChIKey
ZGUKXHGPXOTTSU-UHFFFAOYSA-N
PubChem Compound ID
92613
PubChem Substance ID
44423426, 50966028, 103141917, 104407893, 117402976, 126428224, 135049237, 135649707, 162874411
Target and Pathway
Target(s) Histamine H4 receptor Target Info Agonist [527985]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling events
WikiPathways GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 538783(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1268).
Ref 527985Compared pharmacology of human histamine H3 and H4 receptors: structure-activity relationships of histamine derivatives. Br J Pharmacol. 2006 Apr;147(7):744-54.

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