Drug Information

Drug General Information
Drug ID
D0T7GC
Former ID
DIB020777
Drug Name
Pyr3
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467632]
Formula
C16H11Cl3F3N3O3
InChI
InChI=1S/C16H11Cl3F3N3O3/c1-2-28-15(27)10-7-23-25(12(10)16(20,21)22)9-5-3-8(4-6-9)24-14(26)11(17)13(18)19/h3-7H,2H2,1H3,(H,24,26)
InChIKey
RZHGONNSASQOAY-UHFFFAOYSA-N
PubChem Compound ID
56964346
PubChem Substance ID
135678761, 162249927, 163123003, 178101110, 204361136, 237363704, 241376620, 242817147, 249617973, 252157507, 252451316
Target and Pathway
Target(s) Short transient receptor potential channel 3 Target Info Blocker (channel blocker) [530024]
Pathway Interaction Database Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome Effects of PIP2 hydrolysis
TRP channels
Role of second messengers in netrin-1 signaling
WikiPathways Platelet homeostasis
Netrin-1 signaling
GPCR downstream signaling
Effects of PIP2 hydrolysis
References
Ref 467632(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4293).
Ref 530024Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5400-5.

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