Drug Information

Drug General Information
Drug ID
D0T5TT
Former ID
DNC009377
Drug Name
3-Prop-1-ynylquinoline-8-carboxamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529894]
Formula
C13H10N2O
Canonical SMILES
CC#CC1=CC2=C(C(=CC=C2)C(=O)N)N=C1
InChI
1S/C13H10N2O/c1-2-4-9-7-10-5-3-6-11(13(14)16)12(10)15-8-9/h3,5-8H,1H3,(H2,14,16)
InChIKey
IUUKYHUSWYCGAA-UHFFFAOYSA-N
PubChem Compound ID
25208905
Target and Pathway
Target(s) Poly [ADP-ribose] polymerase-1 Target Info Inhibitor [529894]
KEGG Pathway Base excision repair
NF-kappa B signaling pathway
PANTHER Pathway FAS signaling pathway
Pathway Interaction Database Integrin-linked kinase signaling
Caspase Cascade in Apoptosis
Notch-mediated HES/HEY network
Reactome Dual Incision in GG-NER
WikiPathways FAS pathway and Stress induction of HSP regulation
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Nanoparticle triggered regulated necrosis
Corticotropin-releasing hormone
References
Ref 529894J Med Chem. 2009 Feb 12;52(3):868-77.Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhibitor.
Ref 529894J Med Chem. 2009 Feb 12;52(3):868-77.Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhibitor.

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