Drug Information

Drug General Information
Drug ID
D0T4LT
Former ID
DIB004312
Drug Name
GSK-1842799C
Synonyms
GSK-1842799C; PPI-4691; S1P1 agonists, Praecis
Indication Cardiovascular disorder [ICD10:I00-I99] Investigative [543701]
Company
Praecis Pharmaceuticals Inc
Canonical SMILES
FC(F)(c1c(ccc(c2sc([C@@](C)(N)CO)nn2)c1)OCCCCCCCC)F.C(=<br />O)(/C=C/C(=O)O)O.FC(F)(c1c(ccc(c2sc([C@@](C)(N)CO)nn2)c<br />1)OCCCCCCCC)F
Target and Pathway
Target(s) Sphingosine 1-phosphate receptor 1 Target Info Agonist [543701]
KEGG Pathway FoxO signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
IL2 Signaling Pathway
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
S1P3 pathway
S1P1 pathway
Sphingosine 1-phosphate (S1P) pathway
PDGFR-beta signaling pathway
Reactome G alpha (i) signalling events
Lysosphingolipid and LPA receptors
WikiPathways Signal Transduction of S1P Receptor
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 543701(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 275).
Ref 543701(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 275).

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