Drug Information

Drug General Information
Drug ID
D0S8HZ
Former ID
DNC009376
Drug Name
2-Methylquinoline-8-carboxamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529894]
Formula
C11H10N2O
Canonical SMILES
CC1=NC2=C(C=CC=C2C(=O)N)C=C1
InChI
1S/C11H10N2O/c1-7-5-6-8-3-2-4-9(11(12)14)10(8)13-7/h2-6H,1H3,(H2,12,14)
InChIKey
FKDAECIKJPVBCN-UHFFFAOYSA-N
PubChem Compound ID
21195867
Target and Pathway
Target(s) Poly [ADP-ribose] polymerase-1 Target Info Inhibitor [529894]
KEGG Pathway Base excision repair
NF-kappa B signaling pathway
PANTHER Pathway FAS signaling pathway
Pathway Interaction Database Integrin-linked kinase signaling
Caspase Cascade in Apoptosis
Notch-mediated HES/HEY network
Reactome Dual Incision in GG-NER
WikiPathways FAS pathway and Stress induction of HSP regulation
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Nanoparticle triggered regulated necrosis
Corticotropin-releasing hormone
References
Ref 529894J Med Chem. 2009 Feb 12;52(3):868-77.Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhibitor.
Ref 529894J Med Chem. 2009 Feb 12;52(3):868-77.Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhibitor.

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