Drug Information

Drug General Information
Drug ID
D0S5LT
Former ID
DNC004647
Drug Name
Deoxynojirimycin
Drug Type
Small molecular drug
Indication Pompe's disease [ICD10:E74.02] Phase 3 [530482]
Formula
C6H13NO4
Canonical SMILES
C1C(C(C(C(N1)CO)O)O)O
InChI
1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
InChIKey
LXBIFEVIBLOUGU-JGWLITMVSA-N
PubChem Compound ID
29435
Target and Pathway
Target(s) Maltase-glucoamylase, intestinal Target Info Inhibitor [533823]
Alpha-glucosidase Target Info Inhibitor [533823]
Lysosomal alpha-glucosidase Target Info Inhibitor [529573]
KEGG Pathway Galactose metabolism
Starch and sucrose metabolism
Metabolic pathways
Carbohydrate digestion and absorptionhsa00052:Galactose metabolism
Lysosome
Pathway Interaction Database Notch-mediated HES/HEY network
PathWhiz Pathway Starch and Sucrose MetabolismPW000159:Galactose Metabolism
WikiPathways Metabolism of carbohydrates
References
Ref 530482The pharmacological chaperone 1-deoxynojirimycin increases the activity and lysosomal trafficking of multiple mutant forms of acid alpha-glucosidase. Hum Mutat. 2009 Dec;30(12):1683-92.
Ref 529573Bioorg Med Chem. 2008 Aug 1;16(15):7330-6. Epub 2008 Jun 18.In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures.
Ref 533823J Med Chem. 1994 Oct 28;37(22):3701-6.Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.