Drug Information

Drug General Information
Drug ID
D0S5LH
Former ID
DAP000562
Drug Name
Edrophonium
Synonyms
EDR; Edrophonum; Edroponium; Reversol; Tensilon; EDROPHONIUM ION; Edrophone Chloride; Enlon Plus; ENLON-PLUS; Enlon (TN); Reversol (TN); Tensilon (TN); Ethyl-(3-hydroxyphenyl)-dimethylazanium; Ethyl-(3-hydroxy-phenyl)-dimethyl-ammonium; N-ethyl-3-hydroxy-N,N-dimethylanilinium; N-ethyl-3-hydroxy-N,N-dimethylbenzenaminium; (3-hydroxyphenyl)dimethylethylammonium; 3-hydroxy-N,N-dimethyl-N-ethylanilinium
Drug Type
Small molecular drug
Indication Myasthenia gravis diagnosis [ICD9: 358; ICD10:G70.0] Approved [538168]
Therapeutic Class
Antidotes
Formula
C10H16NO+
Canonical SMILES
CC[N+](C)(C)C1=CC(=CC=C1)O
InChI
1S/C10H15NO/c1-4-11(2,3)9-6-5-7-10(12)8-9/h5-8H,4H2,1-3H3/p+1
InChIKey
VWLHWLSRQJQWRG-UHFFFAOYSA-O
CAS Number
CAS 116-38-1
PubChem Compound ID
3202
PubChem Substance ID
9190, 6212622, 7366196, 7887282, 7979147, 8152037, 11111143, 11111144, 11335984, 11361223, 11363336, 11365898, 11368460, 11374171, 11376622, 11462195, 11466111, 11467231, 11484956, 11485681, 11488926, 11492551, 11494256, 26702965, 26713721, 29222344, 46507530, 47365233, 47365234, 47515350, 47589038, 47662326, 47810792, 48035164, 48110488, 49698977, 50064671, 50100235, 50104222, 50923308, 53788287, 57321660, 58106942, 87350897, 90341680, 103812420, 103951705, 104234195, 104302825, 117617165
Target and Pathway
Target(s) Acetylcholinesterase Target Info Inhibitor [537001], [537124], [537383]
KEGG Pathway Glycerophospholipid metabolism
Cholinergic synapse
PANTHER Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database ATF-2 transcription factor network
PathWhiz Pathway Phospholipid Biosynthesis
WikiPathways Monoamine Transport
Biogenic Amine Synthesis
Acetylcholine Synthesis
Integrated Pancreatic Cancer Pathway
References
Ref 538168FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 040131.
Ref 537001Stabilization of Torpedo californica acetylcholinesterase by reversible inhibitors. Biochemistry. 2009 Jan 27;48(3):563-74.
Ref 537124Neuromuscular blockade, reversal agent use, and operating room time: retrospective analysis of US inpatient surgeries. Curr Med Res Opin. 2009 Apr;25(4):943-50.
Ref 537383Screening of acetylcholinesterase inhibitors by CE after enzymatic reaction at capillary inlet. J Sep Sci. 2009 May;32(10):1748-56.

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