Drug Information

Drug General Information
Drug ID
D0S1VV
Former ID
DNC011237
Drug Name
7-methoxytacrine
Drug Type
Small molecular drug
Indication Discovery agent Terminated [545830]
Formula
C14H16N2O
Canonical SMILES
COC1=CC2=C(C=C1)N=C3CCCCC3=C2N
InChI
1S/C14H16N2O/c1-17-9-6-7-13-11(8-9)14(15)10-4-2-3-5-12(10)16-13/h6-8H,2-5H2,1H3,(H2,15,16)
InChIKey
APQPVVOYBLOJDY-UHFFFAOYSA-N
PubChem Compound ID
119053
Target and Pathway
Target(s) Acetylcholinesterase Target Info Inhibitor [531150]
KEGG Pathway Glycerophospholipid metabolism
Cholinergic synapse
PANTHER Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database ATF-2 transcription factor network
PathWhiz Pathway Phospholipid Biosynthesis
WikiPathways Monoamine Transport
Biogenic Amine Synthesis
Acetylcholine Synthesis
Integrated Pancreatic Cancer Pathway
References
Ref 545830Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004958)
Ref 531150Bioorg Med Chem Lett. 2010 Oct 15;20(20):6093-5. Epub 2010 Aug 16.Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease.

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