Drug Information

Drug General Information
Drug ID
D0R8LB
Former ID
DIB020485
Drug Name
NAEPA
Synonyms
N-acyl ethanolamide phosphate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542012]
Formula
C20H40NO5P
InChI
InChI=1S/C20H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(22)21-18-19-26-27(23,24)25/h9-10H,2-8,11-19H2,1H3,(H,21,22)(H2,23,24,25)/b10-9+
InChIKey
BCSUWOZFWWBYSX-MDZDMXLPSA-N
PubChem Compound ID
17757220
PubChem Substance ID
29217597, 162249980, 178103561, 242369413
Target and Pathway
Target(s) Lysophosphatidic acid receptor Edg-2 Target Info Agonist [529681]
Lysophosphatidate-3 receptor Target Info Agonist [529681]
LPA2 receptor Target Info Agonist [529681]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Gap junction
Pathways in cancerhsa04015:Rap1 signaling pathway
Pathways in cancer
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database LPA receptor mediated eventslysophospholipid_pathway:LPA receptor mediated events
Reactome G alpha (q) signalling events
G alpha (i) signalling events
Lysosphingolipid and LPA receptorsR-HSA-416476:G alpha (q) signalling events
Lysosphingolipid and LPA receptors
WikiPathways Myometrial Relaxation and Contraction Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signalingWP2664:Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signaling
References
Ref 542012(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6982).
Ref 529681LPA and its analogs-attractive tools for elucidation of LPA biology and drug development. Curr Med Chem. 2008;15(21):2122-31.

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