Drug Information

Drug General Information
Drug ID
D0R7HU
Former ID
DNC006233
Drug Name
Pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527871]
Formula
C14H8N2O2
Canonical SMILES
C1=CC=C2C(=C1)C3=C(N2)C=CC4=C3C(=O)NC4=O
InChI
1S/C14H8N2O2/c17-13-8-5-6-10-11(12(8)14(18)16-13)7-3-1-2-4-9(7)15-10/h1-6,15H,(H,16,17,18)
InChIKey
AGFYXNWRDSDSRA-UHFFFAOYSA-N
PubChem Compound ID
18382004
Target and Pathway
Target(s) Poly [ADP-ribose] polymerase-1 Target Info Inhibitor [527871]
KEGG Pathway Base excision repair
NF-kappa B signaling pathway
PANTHER Pathway FAS signaling pathway
Pathway Interaction Database Integrin-linked kinase signaling
Caspase Cascade in Apoptosis
Notch-mediated HES/HEY network
Reactome Dual Incision in GG-NER
WikiPathways FAS pathway and Stress induction of HSP regulation
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Nanoparticle triggered regulated necrosis
Corticotropin-releasing hormone
References
Ref 527871Bioorg Med Chem Lett. 2006 Feb 15;16(4):938-42. Epub 2005 Nov 15.Synthesis and structure-activity relationships of novel poly(ADP-ribose) polymerase-1 inhibitors.
Ref 527871Bioorg Med Chem Lett. 2006 Feb 15;16(4):938-42. Epub 2005 Nov 15.Synthesis and structure-activity relationships of novel poly(ADP-ribose) polymerase-1 inhibitors.

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