Drug Information

Drug General Information
Drug ID
D0R5JD
Former ID
DIB020884
Drug Name
S26131
Synonyms
S 26131; S-26131
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538840]
Formula
C31H34N2O4
InChI
InChI=1S/C31H34N2O4/c1-22(34)32-16-14-26-8-3-6-24-10-12-28(20-30(24)26)36-18-5-19-37-29-13-11-25-7-4-9-27(31(25)21-29)15-17-33-23(2)35/h3-4,6-13,20-21H,5,14-19H2,1-2H3,(H,32,34)(H,33,35)
InChIKey
NSXBZYDTTKLTOH-UHFFFAOYSA-N
PubChem Compound ID
9870523
PubChem Substance ID
14835529, 24161361, 45292784, 76294402, 103176587, 104017966, 135650968, 232681827, 247033574
Target and Pathway
Target(s) Melatonin receptor Target Info Antagonist [526629]
KEGG Pathway Neuroactive ligand-receptor interaction
Circadian entrainment
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 538840(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1362).
Ref 526629New selective ligands of human cloned melatonin MT1 and MT2 receptors. Naunyn Schmiedebergs Arch Pharmacol. 2003 Jun;367(6):553-61. Epub 2003 May 23.

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